Introduction and History of Nolvadex
When it comes to the most popular selective estrogen receptor modulator (SERM), which is commonly also known as an anti -estrogen, Nolvadex is one of the most potent and effective choices for those looking to use a SERM while building muscle and improving their overall body strength. While Nolvadex is an estrogen antagonist, it also functions as an agonist, which means that it works in the same way as estrogen does in various parts of the body, while possessing anti estrogenic functions in other parts, such as breast tissue. Nolvadex is one of the oldest and most popular selective estrogen receptor modulators on the market that is still commonly used as a medicine.
Nolvadex is often used by those individuals using anabolic steroids, however, it is important to remember that it is not an anabolic steroid itself, which can confuse many people as it is used as part of a steroid cycle. Its official name is Tamoxifen Citrate, and it was created in 1961 by the company known as ICI. This company later changed its name to AstraZeneca, and Tamoxifen Citrate was manufactured under the brand name of Nolvadex. The initial use of Tamoxifen citrate was as a treatment option for breast cancer, most notably breast cancer that is hormone responsive. Over the years, it has been used as a preventative treatment against breast cancer. It’s in gain popularity amongst the anabolic steroid community, where it is typically used as an anti estrogen as part of a steroid cycle, which helps to prevent the onset of estrogen related side effects. It is also a popular choice for PCT (Post Cycle Therapy) to aid in the restoration of testosterone.
Actions and Functions of Nolvadex
As has been touched upon above, Nolvadex is a selective estrogen receptor modulator that possesses both antagonist and agonist properties. The way in which it functions is by bonding to estrogen receptors in the location that estrogen would normally have attached itself, which prevents the hormone from undertaking its actions throughout various parts of the body. This is what makes it so useful for those who are suffering from breast cancer. There are many variations of breast cancer that use estrogen as fuel when it attaches itself to the receptors. Ask this action takes place in the chest area, and it also works very well for preventing the development of male breast tissue, also known as gynecomastia. These steroids include Nandrolone, Dianabol, Boldenone, and Testosterone.
It is often seen as being an anti estrogen, it has the potential to also work in the same way as estrogen, especially within the liver. This has been proven to be beneficial, as the livers involvement with estrogen has shown to promote cholesterol at healthier levels. When it comes to those who use anabolic steroids, this possesses many benefits as the majority of anabolic steroids can possess negative effects on cholesterol levels. While Nolvadex is seen as an anti estrogen, it also has potent testosterone stimulation effects. It is able to prevent negative feedback produced by the hypothalamus and pituitary gland by estrogen. This leads to stimulation of the pituitary to release more LH and FSH (luteinizing hormone and follicle-stimulating hormone), which are both necessary for the natural production of testosterone. Without FSH and LH, especially LH, the natural production of testosterone comes to a halt.
Nolvadex Effects in Tissues
The most notable effects of Nolvadex pertain to breast cancer patients, and these are simple in their actions. It is able to effectively block the estrogen hormone from being able to attach, which means that the cancer is deprived of the fuel that it needs to survive. While it is effective, it is not always the first choice of treatment nor the only compound available. AIs (aromatase inhibitors) are typically used at the start of treatment due to their serum estrogen level reducing abilities. Over time, treatment then switches from aromatase Inhibitors to selective estrogen receptor modulators, such as Nolvadex period for prevention, it is often prescribed to those who have a history of breast cancer throughout their family.
For those who use anabolic steroids, Nolvadex as part of a cycle can help prevent gynecomastia. It is not being shown to have particularly beneficial effects with helping to prevent other primary estrogenic effects, such as water retention, but the individual can control this by using different methods. Its ability to be able to prevent the development of gynecomastia means that it is the ideal first choice for those men who are using anabolic steroids. If it is not available, and aromatase inhibitor will need to be used, such as Anastrozole or Letrozole. AIs do have the potential to adversely affect cholesterol levels. When used alone, they do not possess many adverse side effects, but when used in combination with an amortizing steroid, the risk increases 10-fold.
The last effect that Nolvadex provides is the one that the majority of anabolic steroid users find to be the most important. As anabolic steroids will inhibit the production of natural testosterone, kick starting production after completing a cycle is important. If the individual does not suffer from low testosterone condition and no damage occurred to the hpta (hypothalamic pituitary testicular axis) then the natural production of testosterone should occur over a period of months up to a year. This is why a post Cycle Therapy plan is important, and one that includes Nolvadex can help to stimulate testosterone production at a quicker rate. This not only helps the body’s hormone levels to return to normal but also helps to protect and maintain the physique and speed up the recovery process.
As low testosterone production can result in the loss of muscle mass, a PCT plan is absolutely vital and Nolvadex proves to be worth its weight in gold. Plenty of performance enhancing athletes turn their nose up at PCT plans, and if you are only coming off of a cycle for a period of 5 to 6 weeks, then there is no real need to utilize a PCT plan. This is a typical scenario among those who are part of bodybuilding circles, but for the majority of people using anabolic steroids, they are not particularly feasible. This is because the normal anabolic steroid user will have a prolonged period of time off of a cycle, and for the best health and wellness, this is the way to go.
Nolvadex Side Effects
As with all selective estrogen receptor modulators, side effects from Nolvadex are always a possibility. However, it is one of the best rated SERMs available for both women and men. Of course, side effects could well occur, this remains a rare occurrence. Side effects are most likely to affect women than men, but they still remain a limited possibility. Some of the more common side effects associated with Nolvadex include:
Itching, discharge, or bleeding from the vagina
Other side effects associated with Nolvadex use that are much rarer than the above-noted effects include:
A reduction of the white blood cell count
An increase in the triglyceride levels
Rashes over the skin
The above-noted side effects are about all of the ones that can be experienced. While some of them may seem less than ideal, it is important to remember that they are exceedingly rare. It should be mentioned that those women who are trying to become pregnant or are already pregnant should avoid Nolvadex use as it could cause damage to the child in uteri.
Administration of Nolvadex
When looking at Nolvadex for use as a treatment for breast cancer, there are 6 different plans that can consist of female and male treatment. The average dose will typically range from 10 to 20 mg twice a day. It is normal for the initial dose to consist of a 40 mg administration. It is fairly common for the individual to continue dosing with 10 to 20 mg each day indefinitely after all traces of cancer has been eradicated.
As a treatment option for anabolic steroid users looking at preventing estrogenic side effects, the standard dose is 10 to 20 mg each day. If 20 is not able to provide protection from gynecomastia, then the use of an aromatase inhibitor will be required. This is also true if at this dose, however, water retention can typically be prevented with good diet practices. It is commonplace to hear many professional athletes blaming anabolic steroids for their water retention when actually it all comes down to the amount I’ve calories that they are consuming.
When conducting a Post Cycle Therapy plan, the average dose of Nolvadex will typically start at 40 mg each day. This will be continued for several weeks before the amount is reduced to 20 mg each day for another few weeks, and finally reduced down to 10 mg each day. The way in which your cycle ends will play a large role in when Nolvadex will be used.
Nolvadex will begin two weeks after finishing a cycle with an anabolic steroid with a large ester base.
Nolvadex will begin three days after finishing a cycle with an anabolic steroid with a small Ester base.
If you ‘re using HCG, then the timings will be slightly different as listed below.
HCG will begin 10 days after the final injection when using an anabolic steroid with a large Ester base, and Nolvadex will begin after the HCG plan finishes.
HCG will begin 3 days after the final injection when using an anabolic steroid with a small Ester base, and Nolvadex will begin after the HCG plan finishes.
Nolvadex is one of the easiest products on Earth to purchase. In the United States, it does not carry a controlled substance classification, but to have legal possession, a valid prescription will be required. When it comes to the black market, the majority of anabolic steroid outlets will have SERMs available. When it comes to counterfeit products come up this tends to be extremely rare. There are also many research chemical labs that manufacture and sell selective estrogen receptor modulators legally with the use of loopholes. Of course, to purchase these, you would need to do so for research purposes only. However, it is important to note that many research chemical labs provide low quality peptides and other substances. A loss of potency is common, as are unstable ones.
Buying Nolvadex Online
Being able to purchase Nolvadex online is one of the easiest things to do, along with being extremely economical too. Many research chemical labs offer both liquid and tablet forms, but you should remember that purchasing anything from the black market means that you will be breaking the law. And the United States, this can have harsh penalties and fines. While purchasing from an RCL is legal, it is always risky and difficult to prove that the purchase is for genuine research purposes. If you are discovered to have anabolic steroids, then it could become a near impossibility to be able to purchase Nolvadex.
Out of all of the selective estrogen receptor modulators available on the market, both Clomid and Nolvadex are the most favored and abundant. It is important to remember that there are no performance-enhancing benefits from Nolvadex use, with its primary ability being able to help restore natural testosterone production to its normal levels at a faster rate after using anabolic steroids. Nolvadex is fantastic for helping to retain lean muscle mass that has been built while performing a steroid cycle, and this is where its strengths truly lay.
Nolvadex also provides the individual with cardiovascular protective properties and an improvement of good cholesterol levels. When used as part of a Post Cycle Therapy plan, it is one of the best SERMs available and also one of the easiest to obtain. Of course, its main use as a treatment option for breast cancer is always going to be its most vital, but for the anabolic steroid user, you will be hard-pressed to find a better selective estrogen receptor modulator that is easily tolerated and extremely economic.
Nolvadex References & Medical Data:
1. Treatment of marked gynecomastia in puberty with tamoxifen. König R, Schönberger W, Neumann P, Benes P, Grimm W. Klin Padiatr. 1987 Nov-Dec;199(6):389-91. https://www.ncbi.nlm.nih.gov/pubmed/3123765
2. Influence of tamoxifen, aminoglutethimide and goserelin on human plasma IGF-I levels in breast cancer patients. Lien EA, Johannessen DC, Aakvaag A, Lønning PE. J Steroid Biochem Mol Biol. 1992 Mar;41(3-8):541-3. https://www.ncbi.nlm.nih.gov/pubmed/1532904
3. Activation of the somatotropic axis by testosterone in adult males: evidence for the role of aromatization. Weissberger AJ, Ho KK. J Clin Endocrinol Metab. 1993 Jun;76(6):1407-12. https://www.ncbi.nlm.nih.gov/pubmed/8501143
4. Hormonal effects of an antiestrogen, tamoxifen, in normal and oligospermic men. Vermeulen A, Comhaire F. Fertil Steril. 1978 Mar;29(3):320-7. https://www.ncbi.nlm.nih.gov/pubmed/640052
5. Comparative clinical pharmacology and pharmacokinetic interactions of aromatase inhibitors. Boeddinghaus IM, Dowsett M. J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):85-91. https://www.ncbi.nlm.nih.gov/pubmed/11850211
6. Aromatase inhibitors: cellular and molecular effects. Miller WR, Anderson TJ, White S, Larionov A, Murray J, Evans D, Krause A, Dixon JM. J Steroid Biochem Mol Biol. 2005 May;95(1-5):83-9. https://www.ncbi.nlm.nih.gov/pubmed/16002280